Once I start a game with a program specific settings (CS:GO or Battlefield V with Vsync disabled) the settings are lost. The last test that I did, yesterday (Jul 27 2020), using the most recent driver (451.67), w/ the Nvidia Control Panel being installed by the Microsoft Store, the specific settings are not being save (or being overwritten)
Recently, from my already sold GTX 1050 ti (not exactly sure of what Nvidia driver Version), I see some inconsistencies on the Nvidia Control Panel. From my old FX5200 128MB to my newer Zotac 1660 Super, always check the settings in the panel.
Thing is, I'm always used to play around with the Nvidia Control Panel settings and check which settings fits the best for the games I play and the performance of the GPU. Newbie on the forums here, however long run hardware fanboy.